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Diethyl DL-Malate is used as a reagent in the synthesis of dicarboxylic nitroxyalkylamides and nitroxyalkylimides as anti-ischemic agents.
Diethyl malate is quite frequently used in flavour compositions, mainly for imitation Apples and Rum. The concentration in the finished consumer product may be about 20 to 25 ppm or up to 45 ppm in baked goods.